Mechanism of action
Ciclosporin belongs to a group of drugs that suppress the immune system, are able to inhibit the development of the first stage of T-lymphocyte activation. At the same time, the drug also inhibits the release of meds. chemotherapy has the ability to cause inflammation from basophils, neutrophils.
The drug comes in the form of injections and oral forms, the doctor will specify the appropriate format for each patient.
Indications for use
The drug is used for the treatment of psoriasis from moderate to severe. In addition, the drug is also effective when treating pustules, psoriasis and nail damage.
Suggest some effective medications for psoriasis
Compliance with your doctor's prescription is the best way to effectively treat your illness: Use an initial dose of ciclosporin about 2.5mg / kg / day twice daily. After 4 weeks of oral administration, depending on the disease status can increase the dose up to a maximum of 4mg / kg / day. According to statistics, most of the patients taking a ciclosporin dose of 3mg / kg / day, the recurrence rate is 42% and about 50% of the patients who stop the drug will relapse after 4 months.
Because Ciclosporin is usually recommended to be used continuously for about 12 weeks to treat psoriasis. The longer it is used, the higher the risk of toxicity. Therefore, it is best to have an appropriate alternative to the patient before or after stopping Coclosporin.
Side effects
Some of the side effects that can occur with ciclosporin use include:
- Nausea
- Diarrhea
- Muscle pain
- Headache
- Shivering
- Hypertension
- Cumulative renal toxicity
- Increased blood glycerid
- Increased liver enzymes
- Increased risk of infection
- Risk of skin cancer
Contraindicated for use
Since the drug has a very strong immunosuppressive effect, it is contraindicated for use in patients with hepatitis C virus and HIV.
Contraindicated for pregnant and lactating women.
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