Because of its dermatological nature, there are certainly many people wondering "what should be applied with psoriasis?" Currently, there are many topical drugs available for the treatment of psoriasis and the choice of the appropriate drug depends on the type of disease, the severity of the disease, the drug used alone or in combination ...
Some of the following drugs can be mentioned:
Corticosteroids
Corticosteroids are the most used topical psoriasis medications today. The drug works to help minimize symptoms of red skin, scaly, anti-inflammatory, immunosuppressive, causing vasoconstriction. The drug is formulated in the form of ointment to enhance permeability and is strong.
Corticosteroids are classified into active potency according to the levels: extreme (I), strong (II), moderate (III, IV, V), mild (VI) and weak (VII).
However, this drug should only be used within 2-4 weeks, if used for longer can cause some side effects such as degeneration of the skin, thinning of the epidermis, causing superinfection of bacteria or fungi.
Corticosteroids are the most used topical psoriasis medications today
Calcipotriol
Calcipotriol is quite effective against psoriasis, it is believed to be more effective than the class III corticosteroid. With the mechanism of action of binding to vitamin D receptors, it inhibits the proliferation of keratin, inhibits the activity of T-lymphocytes.
Features when using Tacrolimus are easy skin irritation, burning sensation, contact dermatitis when applied, especially in the face. It may even increase blood calcium and inhibit parathyroid hormone when the drug is overused at doses higher than 5mg / week.
Tazaroten
Tazarotene is a third-generation topical retinoid that is sold as a topical cream. It normalizes the abnormal differentiation of keratinocytes, thereby reducing keratinization and infiltration.
During the use of the drug can cause acne, burning, reddened skin.
Tacrolimus
Tacrolimus is often used as a replacement for corticosteroids in cases of damaged facial skin or folds where corticosteroids are not recommended to apply for long periods of time. Tacrolimus 0.1% has good anti-inflammatory effect with specific protein binding mechanism inside the protoplasm of T-lymphocytes.
The drug also inadvertently causes dermatitis, erythema, skin irritation, burning pain, edema at the site of application, and skin infection. The use of this drug is not recommended in conjunction with UVB psoriasis treatments.
Effective psoriasis medications
The use of topical medicines saves time and costs on treatment
Salicylic acid
Salicylic acid is a substance that helps to destroy keratosis, it helps increase the amount of moisture inside the skin, then breaks down the bonding of keratinocytes together on the psoriasis skin.
The topical course of the drug can cause irritation and systemic salicylic syndrome (including nausea, hypoventilation).
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